Bhavya Malla

Doctor of pharmacy

IVERMECTIN IN COVID

2 June 2021

Ivermectin is an Semisynthetic Anti - Helmintic agent. It was an In-vitro study which showed that single treatment can affect 5000 fold reduction in virus within 48hrs.

Recent studies have shown that Ivermectin also has anti-viral property too which is effective against

  • HIV

  • DENGUE

  • SIMIAN VIRUS

  • ZIKA VIRUS

  • INFLUENZA VIRUS

  • SARS-CoV-2

What Happens When SARS-Co-2 enters into HOST CELL?

  • SARS-Co-2 has RNA in it. On the RNA of the virus there are multiple protein molecules among them one is S-Spike protein.

  • This protein molecule is very important because it helps the virus to get attached to human cell receptors.

  • The Human Cell Surface contains a receptor named ACE-2 receptor.

  • To this ACE-2 receptor the spike protein will get attached and undergo endocytosis to enter into the cell.

  • The Endosome which consists of viral RNA is now released into the cytosol.

  • Then this RNA enters into RIBOSOME and starts making different protein molecules.

  • These protein molecules are nothing but different structural proteins of the virus.

  • The initial protein made by the ribosome has a very long polypeptide chain.

  • These long polypeptides are broken down into Functional proteins.

  • Sometimes the viral RNA uses an enzyme called RNA dependent RNA Polymerase to synthesize more RNA molecules.

  • The cell has Nucleus consisting of DNA molecules. Every nucleated cell has a DNA that codes for Anti-viral properties.

  • The viral protein enters into Nucleus to deactivate the antiviral property of DNA and enhances viral spread.

  • But the viral protein cannot enter the nucleus directly; they need some special carrier molecules for transportation.

  • Importin α and Importin β1 hetero dimers are the special carrier molecules.

  • The SARS-Co-2 virus protein present in the cytoplasm attaches to the Importin forming a complex and gets transferred through the Nuclear pore complex and enters into the host nucleus.

  • In the nucleus the complex gets separated, the viral protein now inhibits the DNA Antiviral activity responses leading to increase in the infection.

How does Ivermectin work in SARS-Co-2?

  • After giving Ivermectin it enters into the host cell and binds to importin and destabilize the Hetero dimer.

  • So now the viral protein cannot bind with the importin molecule and cannot enter the host cell nucleus.

  • This results in maintenance of the Antiviral property of DNA.

Side effects associated with IVERMECTIN.

  • Headache

  • Dizziness

  • Muscle pain

  • Nausea

  • Diarrhoea

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Priyanka anjinappa

2 June 2021, 3:47:26 pm

Great explanation

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