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Amitriptyline induces Thrombocytopenia ?

Query :

Either amitriptyline causes bone marrow suppression and Immunosupression ? If yes what are incidences.

Answer :

Rarely causes Thrombocytopenia.

Additional Information:

Amitriptyline is a Tricyclic antidepressants that inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of amitriptyline.

The drug also has a strong anticholinergic effect.

Fractures: Bone fractures have been associated with antidepressant treatment. Consider the possibility of a fragility fracture if an antidepressant-treated patient presents with unexplained bone pain, point tenderness, swelling, or bruising. •

Hematologic effects: TCAs may rarely cause bone marrow suppression; monitor for any signs of infection and obtain CBC if symptoms (eg, fever, sore throat) evident. Bone marrow depression (including agranulocytosis, leukopenia, and thrombocytopenia), eosinophilia, purpura Some people who take this drug may get a very bad muscle problem called tardive dyskinesia. The risk may be greater in older adults, mainly women. The chance that this will happen or that it will never go away is greater in people who take this drug in higher doses or for a long time. Muscle problems may also occur after short-term use with low doses or muscle problems with tongue, face, mouth, or jaw like tongue sticking out, puffing cheeks, mouth puckering, or chewing.

Have to ask anything regarding above query, please comment below.

References

“Product Information. Sinequan (doxepin).” Roerig Division, New York, NY. Hunt KA, Resnick MP “Clomipramine-induced agranulocytosis and its treatment with G-CSF.” Am J Psychiatry 150 (1993): 522-3 “Product Information. Anafranil (clomipramine).” Basel Pharmaceuticals, Summit, NJ. Souhami RL, Ashton CR, Lee-Potter JP “Agranulocytosis and systemic candidiasis following clomipramine therapy.” Postgrad Med J 52 (1976): 472-4 “Product Information. Surmontil (trimipramine)” Wyeth-Ayerst Laboratories, Philadelphia, PA. “Product Information. Tofranil (imipramine).” Novartis Pharmaceuticals, East Hanover, NJ. Magni G, Urbani A, Silvestro A, Grassetto M “Clomipramine-induced pancytopenia.” J Nerv Ment Dis 175 (1987): 309-10 Wolf B, Conradty M, Grohmann R, Ruther E, Witzgall H, Londong V “A case of immune complex hemolytic anemia, thrombocytopenia, and acute renal failure associated with doxepin use.” J Clin Psychiatry 50 (1989): 99-100 Albertini RS, Penders TM “Agranulocytosis associated with tricyclics.” J Clin Psychiatry 39 (1978): 483-5 “Product Information. Pamelor (nortriptyline).” Sandoz Pharmaceuticals Corporation, East Hanover, NJ. “Product Information. Ludiomil (maprotiline).” Ciba-Geigy Pharmaceuticals, East Hanover, NJ. “Product Information. Norpramin (desipramine).” Hoechst Marion-Roussel Inc, Kansas City, MO. “Product Information. Vivactil (protriptyline)” Merck & Co, Inc, West Point, PA. “Product Information. Elavil (amitriptyline).” Stuart Pharmaceuticals, Wilmington, DE. Gravenor DS, Leclerc JR, Blake G “Tricyclic antidepressant agranulocytosis.” Can J Psychiatry 31 (1986): 661 Draper BM, Manoharan A “Neutropenia with cross-intolerance between two tricyclic antidepressant agents.” Med J Aust 146 (1987): 452-3

#amitriptyline #DrSahityaKurapati #Thrombocytopenia

#amitriptyline

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