A natural compound isolated from onions may help treat ovarian cancer, a new study has claimed. Researchers from Kumamoto University in Japan studied the effects of onion in A (ONA) on a preclinical model of epithelial ovarian cancer (EOC) both in vivo and in vitro. Previously , researchers found that ONA suppressed pro-tumour activation of host myeloid cells.
According to WHO, EOC is the most common type of ovarian cancer and has a five-year survival rate of about 40%. researchers said.
The group’s in vitro experiments showed that EOCs, which usually proliferate in the presence of pro-tumour M2 macrophages, showed inhibited growth after introduction of ONA. This was thought to be due to ONA influence on STAT3, a transcription factor known to be involved in both M2 polarisation and cancer cell proliferation.
The team also found that ONA inhibited the pro-tumour functions of myeloid-derived suppressor cells, which are associated with the suppression of the anti-tumour immune response of host lymphocytes, by using preclinical sarcoma model. ONA was also found to enhance the effects of anti-cancer drugs by strengthening their anti proliferation capabilities.
Source : Online News