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High rate of asymptomatic COVID-19 cases could help end pandemic

High rate of asymptomatic COVID-19 cases 'good thing' for society, could help end pandemic.In the last seven months, the COVID-19 pandemic has infected over 20 million people globally while it has claimed more than 700,000 lives, as per the Johns Hopkins University. The research by Monica Gandhi, an infectious-disease specialist at the University of California at San Francisco, is based on asymptomatic cases, which form a large part of the infection history, according to The Washington Post.

"A high rate of asymptomatic infection is a good thing. It is a good thing for the individual and a good thing for society," Gandhi was quoted as saying.

The COVID-19 pandemic has thrown up several clues -- the uneven transmission in various parts of the world and mostly mild impact on children. According to the United States Centres for Disease Control and Prevention last month, 40 per cent of people infected with the virus are asymptomatic.

These developments have allowed scientists to look into the role of the receptor cells, which the virus uses to infiltrate the body and to get a better understanding of the role that age and genetics might play. Others are researching about face masks and whether they may filter out enough virus so that those wearing them had mild cases or no symptoms.

When coronavirus first surfaced in December last year, health authorities labelled it a "novel" virus as it was the first time it was seen in humans who presumably had no immunity from the infection. However, this early and tentative evidence suggests that the assumption might have been incorrect.

One interesting hypothesis states that a part of the world's population may have partial protection due to "memory" T cells, a part of our immune system trained to recognise specific invaders. This may arise from cross-protection derived from standard childhood vaccinations, as per The Washington Post.

"This might potentially explain why some people seem to fend off the virus and may be less susceptible to becoming severely ill," National Institutes of Health Director Francis Collins was quoted as saying.

This could be far-reaching if such findings are validated on a population level.

Hans-Gustaf Ljunggren, a researcher at Sweden's Karolinska Institute and others have suggested that public immunity to COVID-19 could be significantly higher as per the recommendations by serology studies.

But Anthony S Fauci, the US' top infectious-disease expert, stated in an interview that such theories are premature even as these ideas are being studied deeply. However, he acknowledged that partial pre-existing immunity in some individuals seems a possibility.

Fauci warned that there are many likely reasons -- including youth and general health -- which decides whether a particular person shrugs off the disease or dies of it. He stated that even those with mild illness may have lingering medical problems, The Washington Post reported.

"There are so many other unknown factors that may determine why someone gets an asymptomatic infection. It is a very difficult problem to pinpoint one thing," Fauci said.

In an article published in the Journal of General Internal Medicine earlier this month, Gandhi said 15 people of the infected were asymptomatic in some early outbreaks of the pandemic, in which most people did not wear masks. But when people started to wear masks, the rate of asymptomatic patients was between 40 to 45 per cent.

"It is an intriguing hypothesis that asymptomatic infection triggering immunity may lead us to get more population-level immunity. That itself will limit spread," Gandhi noted.


Source: ANI news

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